MolNFT v1 · #179746 · protein
Factor H enhancing human antibody fragment (Fab) to meningococcal factor H binding protein
7KET · Immunoglobulin gamma, kappa light chain: “Factor H enhancing human antibody fragment (Fab) to meningococcal factor H binding protein”. X-ray diffraction, 7 pockets (best druggability 0.61). MolNFT v1 #179746 on GenesisL1: 3D…
- PDB
- 7KET
- Type
- protein
- Length
- 668 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin gamma, kappa light chain; Immunoglobulin gamma, heavy chain fd fragment…
- UniProt
- Q6VRZ6
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Immunoglobulin gamma, kappa light chain | protein | 209 | 6% helix, 47% strand | — |
| A | Immunoglobulin gamma, heavy chain fd fragment | protein | 217 | 6% helix, 51% strand | — |
| C | Factor H binding protein | protein | 242 | 6% helix, 59% strand | Q6VRZ6 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 459 | 0.61 | 0.76 | 50 | empty |
| 2 | 68 | 0.61 | 0.91 | 29 | empty |
| 3 | 256 | 0.55 | 0.77 | 37 | empty |
| 4 | 203 | 0.47 | 0.74 | 30 | empty |
| 5 | 58 | 0.43 | 0.82 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1639 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 604 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 279 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7KET · Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6VRZ6
- Elsewhere: RCSB PDB 7KET · PDBe 7KET · UniProt Q6VRZ6
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