MolNFT v1 · #179711 · protein
Human TOM70 in complex with SARS COV2 ORF9B
7KDT · Mitochondrial import receptor subunit TOM70: “Human TOM70 in complex with SARS COV2 ORF9B”. Electron microscopy, 6 pockets (best druggability 0.77). MolNFT v1 #179711 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KDT
- Type
- protein
- Length
- 505 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial import receptor subunit TOM70; ORF9B protein
- UniProt
- O94826, P0DTD2
- Pockets
- 6 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial import receptor subunit TOM70 | protein | 467 | 77% helix, 0% strand | O94826 |
| B | ORF9B protein | protein | 38 | 53% helix, 0% strand | P0DTD2 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.77 | 0.89 | 31 | empty |
| 2 | 453 | 0.75 | 0.84 | 65 | empty |
| 3 | 73 | 0.73 | 0.97 | 19 | empty |
| 4 | 265 | 0.64 | 0.82 | 37 | empty |
| 5 | 84 | 0.43 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2042 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94826
- Every structure of UniProt P0DTD2
- Elsewhere: RCSB PDB 7KDT · PDBe 7KDT · UniProt O94826 · UniProt P0DTD2
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