MolNFT v1 · #179669 · protein
Reconstructed ancestor of hiuases and transthyretins
7KCN · Hiuase-ttr ancestor: “Reconstructed ancestor of hiuases and transthyretins”. X-ray diffraction, 1 ligand (PO4), 1 pocket (best druggability 0.45). MolNFT v1 #179669 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KCN
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hiuase-ttr ancestor
- Ligands
- PO4
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hiuase-ttr ancestor | protein | 114 | 9% helix, 45% strand | — |
| B | Hiuase-ttr ancestor | protein | 117 | 6% helix, 40% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.45 | 0.77 | 32 | PO4, EDO |
Interfaces
1 interface between chains.
- A–B · 481 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7KCN · Reconstructed ancestor of HIUases and Transthyretins · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KCN · PDBe 7KCN
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