MolNFT v1 · #179637 · protein
Herceptin diabody with R83T, E85C mutations
7KBP · Single-chain fv: “Herceptin diabody with R83T, E85C mutations”. X-ray diffraction. MolNFT v1 #179637 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KBP
- Type
- protein
- Length
- 931 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single-chain fv
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Single-chain fv | protein | 233 | 4% helix, 52% strand | — |
| B | Single-chain fv | protein | 235 | 5% helix, 49% strand | — |
| C | Single-chain fv | protein | 230 | 7% helix, 50% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · 17 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- B–C · 243 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7KBP · Herceptin Diabody with R83T, E85C Mutations · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KBP · PDBe 7KBP
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