MolNFT v1 · #179625 · protein + DNA
Nucleosome in interphase chromosome formed in xenopus egg extract (oligo fraction)
7KBD · Histone H3.2: “Nucleosome in interphase chromosome formed in xenopus egg extract (oligo fraction)”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #179625 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7KBD
- Type
- protein + DNA
- Length
- 1,057 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3.2; Histone H4; Histone H2A; Histone H2B 1.1; DNA (151-mer)
- UniProt
- P84233, P62799, Q6DKE3, P02281
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 9 distinct chains · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Histone H3.2 | protein | 97 | 59% helix, 4% strand | P84233 |
| B | Histone H4 | protein | 83 | 59% helix, 7% strand | P62799 |
| C | Histone H2A | protein | 104 | 49% helix, 6% strand | Q6DKE3 |
| D | Histone H2B 1.1 | protein | 94 | 72% helix, 4% strand | P02281 |
| F | Histone H4 | protein | 81 | 59% helix, 6% strand | P62799 |
| G | Histone H2A | protein | 106 | 55% helix, 6% strand | Q6DKE3 |
| H | Histone H2B 1.1 | protein | 93 | 72% helix, 4% strand | P02281 |
| I | DNA (151-mer) | dna | 151 | — | — |
| J | DNA (151-mer) | dna | 151 | — | — |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 638 | 0.79 | 0.84 | 73 | empty |
| 2 | 418 | 0.73 | 0.84 | 47 | empty |
| 3 | 377 | 0.71 | 0.83 | 49 | empty |
| 4 | 165 | 0.70 | 0.89 | 29 | empty |
| 5 | 179 | 0.70 | 0.88 | 28 | empty |
Interfaces
38 interfaces between chains.
- I–J · 6706 Ų buried · 524 hydrogen bonds · nucleic-nucleic
- A–B · 2669 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 2632 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2594 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 2590 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7KBD · Nucleosome in interphase chromosome formed in Xenopus egg extract (oligo fraction) · the same entry in another collection · chain J against J, TM-score 1.00
- P84233 · AlphaFold monomer V2.0 prediction for histone H3.2 (P84233) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84233
- Every structure of UniProt P62799
- Every structure of UniProt Q6DKE3
- Every structure of UniProt P02281
- Elsewhere: RCSB PDB 7KBD · PDBe 7KBD · UniProt P84233 · UniProt P62799 · UniProt Q6DKE3 · UniProt P02281
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