MolNFT v1 · #179621 · protein
The structure of a sensor domain of a histidine kinase (vxra) from vibrio cholerae O1 biovar eltor str. N16961, D238-T240 deletion mutant
7KB9 · Sensor histidine kinase: “The structure of a sensor domain of a histidine kinase (vxra) from vibrio cholerae O1 biovar eltor str.…”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #179621 on GenesisL1: 3D…
- PDB
- 7KB9
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor histidine kinase
- UniProt
- Q9KM24
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor histidine kinase | protein | 216 | 49% helix, 16% strand | Q9KM24 |
| B | Sensor histidine kinase | protein | 215 | 49% helix, 15% strand | Q9KM24 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.40 | 0.76 | 16 | EDO |
| 2 | 66 | 0.33 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1643 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7KB9 · THE STRUCTURE OF A SENSOR DOMAIN OF A HISTIDINE KINASE (VxrA) FROM VIBRIO CHOLERAE O1… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KM24
- Elsewhere: RCSB PDB 7KB9 · PDBe 7KB9 · UniProt Q9KM24
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