MolNFT v1 · #179613 · protein

O-acety-L-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima with pyridoxal-5-phosphate (plp) bound in the internal aldimine state

7KB0 · O-acetyl-L-homoserine sulfhydrylase: “O-acety-L-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima with pyridoxal-5-phosphate…”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #179613 on…

PDB: 7KB0
Type: protein
Length: 428 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: O-acetyl-L-homoserine sulfhydrylase
EC: 2.5.1.-
UniProt: Q9WZY4
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	O-acetyl-L-homoserine sulfhydrylase (EC 2.5.1.-)	protein	428	41% helix, 14% strand	Q9WZY4

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	310	0.61	0.78	29	empty
2	60	0.27	0.73	23	empty

Modifications

Observed in the structure: 1 modified (cofactor).

Compared structures

7KB0 · O-acety-L-homoserine aminocarboxypropyltransferase (MetY) from Thermotoga maritima with… · the same entry in another collection · chain A against A, TM-score 1.00
Q9WZY4 · AlphaFold monomer V2.0 prediction for O-acetyl-L-homoserine sulfhydrylase (Q9WZY4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WZY4
Elsewhere: RCSB PDB 7KB0 · PDBe 7KB0 · UniProt Q9WZY4

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