MolNFT v1 · #179553 · protein
Crystal structure of human CPSF30 in complex with HFIP1
7K95 · Isoform 2 of cleavage and polyadenylation specificity…: “Crystal structure of human CPSF30 in complex with HFIP1”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #179553 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7K95
- Type
- protein
- Length
- 123 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of cleavage and polyadenylation specificity factor subunit 4; Pre-mRNA…
- UniProt
- Q6UN15
- Ligands
- ZN
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of cleavage and polyadenylation specificity factor subunit 4 | protein | 53 | 30% helix, 11% strand | — |
| B | Pre-mRNA 3'-end-processing factor FIP1 | protein | 39 | 49% helix, 3% strand | Q6UN15 |
| C | Pre-mRNA 3'-end-processing factor FIP1 | protein | 31 | 39% helix, 3% strand | Q6UN15 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- A–B · 819 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 517 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 335 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7K95 · Crystal structure of human CPSF30 in complex with hFip1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q6UN15 · AlphaFold monomer V2.0 prediction for pre-mRNA 3'-end-processing factor FIP1 (Q6UN15) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UN15
- Elsewhere: RCSB PDB 7K95 · PDBe 7K95 · UniProt Q6UN15
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