MolNFT v1 · #17955 · protein
Crystal structure of N-terminal domain of human platelet receptor glycoprotein ib-alpha at 1.7 ångström resolution
1P9A · Platelet glycoprotein ib alpha chain precursor: “Crystal structure of N-terminal domain of human platelet receptor glycoprotein ib-alpha at 1.7 ångström…”. X-ray diffraction, 2 ligands (NAG, BMA), 1 pocket (best druggability 0.37).…
- PDB
- 1P9A
- Type
- protein
- Length
- 266 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Platelet glycoprotein ib alpha chain precursor
- UniProt
- P07359
- Ligands
- NAG, BMA
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Platelet glycoprotein ib alpha chain precursor | protein | 266 | 9% helix, 15% strand | P07359 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains G
- BMA · beta-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.37 | 0.74 | 22 | empty |
Modifications
Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 1P9A · Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha… · the same entry in another collection · chain G against G, TM-score 1.00
- P07359 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (P07359) · a predicted model of the same protein · chain G against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07359
- Elsewhere: RCSB PDB 1P9A · PDBe 1P9A · UniProt P07359
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