MolNFT v1 · #179540 · protein
Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment, C110
7K8P · C110 Fab heavy chain: “Crystal structure of an anti-SARS-cov-2 human neutralizing antibody Fab fragment, C110”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #179540 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7K8P
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C110 Fab heavy chain; C110 Fab light chain
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | C110 Fab heavy chain | protein | 216 | 8% helix, 51% strand | — |
| L | C110 Fab light chain | protein | 210 | 6% helix, 52% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 303 | 0.52 | 0.74 | 47 | empty |
| 2 | 54 | 0.46 | 0.85 | 21 | empty |
Interfaces
1 interface between chains.
- H–L · 1693 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7K8P · Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7K8P · PDBe 7K8P
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