MolNFT v1 · #17925 · protein
Crystal structure of TM1620 (APC4843) from thermotoga maritima
1P8C · Conserved hypothetical protein: “Crystal structure of TM1620 (APC4843) from thermotoga maritima”. X-ray diffraction, 8 pockets (best druggability 0.81). MolNFT v1 #17925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1P8C
- Type
- protein
- Length
- 696 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved hypothetical protein
- UniProt
- Q9X1V5
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 5 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved hypothetical protein | protein | 111 | 71% helix, 0% strand | Q9X1V5 |
| B | Conserved hypothetical protein | protein | 114 | 74% helix, 0% strand | Q9X1V5 |
| C, E | Conserved hypothetical protein | protein | 119 | 78% helix, 0% strand | Q9X1V5 |
| D | Conserved hypothetical protein | protein | 118 | 78% helix, 0% strand | Q9X1V5 |
| F | Conserved hypothetical protein | protein | 115 | 78% helix, 0% strand | Q9X1V5 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 841 | 0.81 | 0.84 | 77 | empty |
| 2 | 166 | 0.60 | 0.83 | 34 | empty |
| 3 | 94 | 0.59 | 0.87 | 19 | empty |
| 4 | 172 | 0.57 | 0.81 | 31 | empty |
| 5 | 237 | 0.55 | 0.77 | 24 | empty |
Interfaces
15 interfaces between chains.
- B–C · 1242 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 1238 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 1213 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 902 Ų buried · 14 hydrogen bonds · protein-protein
- C–F · 901 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1P8C · Crystal structure of TM1620 (APC4843) from Thermotoga maritima · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X1V5
- Elsewhere: RCSB PDB 1P8C · PDBe 1P8C · UniProt Q9X1V5
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