MolNFT v1 · #179237 · protein
The cryo-EM structure of the glutamate decarboxylase from escherichia COLI
7JZH: “The cryo-EM structure of the glutamate decarboxylase from escherichia COLI”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #179237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JZH
- Type
- protein
- Length
- 2,562 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate decarboxylase
- EC
- 4.1.1.15
- UniProt
- A5YKJ2
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 41% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Glutamate decarboxylase (EC 4.1.1.15) | protein | 427 | 41% helix, 10% strand | A5YKJ2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.84 | 0.85 | 120 | empty |
| 2 | 685 | 0.79 | 0.84 | 83 | empty |
| 3 | 451 | 0.79 | 0.87 | 76 | empty |
| 4 | 732 | 0.75 | 0.80 | 71 | empty |
| 5 | 674 | 0.74 | 0.81 | 68 | empty |
Interfaces
12 interfaces between chains.
- B–C · 3560 Ų buried · 28 hydrogen bonds · protein-protein
- A–D · 3534 Ų buried · 24 hydrogen bonds · protein-protein
- E–F · 3528 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2233 Ų buried · 13 hydrogen bonds · protein-protein
- D–F · 2204 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7JZH · The Cryo-EM structure of the Glutamate decarboxylase from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5YKJ2
- Elsewhere: RCSB PDB 7JZH · PDBe 7JZH · UniProt A5YKJ2
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