MolNFT v1 · #179041 · protein

Structure of SARS-cov-2 ORF8 accessory protein

7JTL · ORF8 protein: “Structure of SARS-cov-2 ORF8 accessory protein”. X-ray diffraction, 1 ligand (NA), 5 pockets (best druggability 0.54). MolNFT v1 #179041 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JTL
Type: protein
Length: 203 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ORF8 protein
UniProt: P0DTC8
Ligands: NA
Pockets: 5 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ORF8 protein	protein	102	0% helix, 46% strand	P0DTC8
B	ORF8 protein	protein	101	0% helix, 47% strand	P0DTC8

Ligands and binding sites

NA · Sodium ion · metal · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.54	0.78	32	NA
2	117	0.41	0.75	20	empty
3	59	0.38	0.80	14	empty
4	50	0.36	0.80	13	empty
5	87	0.35	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 758 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

7JTL · Structure of SARS-CoV-2 ORF8 accessory protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC8
Elsewhere: RCSB PDB 7JTL · PDBe 7JTL · UniProt P0DTC8

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