MolNFT v1 · #178976 · protein
Chlamydomonas reinhardtii radial spoke head and neck (recombinant)
7JRJ · Radial spoke protein 10: “Chlamydomonas reinhardtii radial spoke head and neck (recombinant)”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #178976 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JRJ
- Type
- protein
- Length
- 3,059 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radial spoke protein 10; Flagellar radial spoke protein 1; Nucleoside diphosphate kinase…
- EC
- 2.7.4.6, 1.-.-.-
- UniProt
- Q27YU4, Q27YU0, Q69B19, Q6UBQ3, P12759, Q27YU7, Q27YU5, Q01656, Q01657
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 14 distinct chains · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Radial spoke protein 10 | protein | 180 | 0% helix, 59% strand | Q27YU4 |
| F | Flagellar radial spoke protein 1 | protein | 356 | 16% helix, 35% strand | Q27YU0 |
| K | Nucleoside diphosphate kinase 6 (EC 2.7.4.6) | protein | 158 | 47% helix, 15% strand | Q69B19 |
| I | Flagellar radial spoke protein 2 | protein | 327 | 55% helix, 11% strand | Q6UBQ3 |
| J | Unknown protein | protein | 4 | 0% helix, 25% strand | — |
| G | Flagellar radial spoke protein 3 | protein | 148 | 82% helix, 0% strand | P12759 |
| H | Flagellar radial spoke protein 5 (EC 1.-.-.-) | protein | 477 | 43% helix, 12% strand | Q27YU7 |
| A, B | Radial spoke protein 9 | protein | 252 | 23% helix, 33% strand | Q27YU5 |
| C | Flagellar radial spoke protein 4 | protein | 359 | 26% helix, 18% strand | Q01656 |
| D | Flagellar radial spoke protein 6 | protein | 422 | 26% helix, 16% strand | Q01657 |
| L | Flagellar radial spoke protein 6 | protein | 6 | 0% helix, 0% strand | — |
| M | Flagellar radial spoke protein 10 | protein | 5 | 0% helix, 40% strand | — |
| N | Flagellar radial spoke protein 1 | protein | 64 | 0% helix, 38% strand | — |
| O | Flagellar radial spoke protein 2 | protein | 49 | 73% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1044 | 0.89 | 0.91 | 135 | empty |
| 2 | 780 | 0.88 | 0.92 | 81 | empty |
| 3 | 991 | 0.82 | 0.83 | 102 | empty |
| 4 | 697 | 0.81 | 0.85 | 74 | empty |
| 5 | 273 | 0.80 | 0.92 | 41 | empty |
Interfaces
33 interfaces between chains.
- B–D · 2269 Ų buried · 27 hydrogen bonds · protein-protein
- F–C · 2208 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2027 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 1541 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1446 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7JRJ · Chlamydomonas reinhardtii radial spoke head and neck (recombinant) · the same entry in another collection · chain O against O, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q27YU4
- Every structure of UniProt Q27YU0
- Every structure of UniProt Q69B19
- Every structure of UniProt Q6UBQ3
- Every structure of UniProt P12759
- Every structure of UniProt Q27YU7
- Every structure of UniProt Q27YU5
- Every structure of UniProt Q01656
- Every structure of UniProt Q01657
- Elsewhere: RCSB PDB 7JRJ · PDBe 7JRJ · UniProt Q27YU4 · UniProt Q27YU0 · UniProt Q69B19 · UniProt Q6UBQ3 · UniProt P12759 · UniProt Q27YU7 · UniProt Q27YU5 · UniProt Q01656 · UniProt Q01657
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