MolNFT v1 · #178966 · protein
Chlamydomonas reinhardtii radial spoke minimal head complex
7JR9 · Radial spoke protein 9: “Chlamydomonas reinhardtii radial spoke minimal head complex”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #178966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JR9
- Type
- protein
- Length
- 1,314 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radial spoke protein 9; Flagellar radial spoke protein 4; Flagellar radial spoke protein…
- UniProt
- Q27YU5, Q01656, Q01657, Q27YU4
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 7 distinct chains · 19% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Radial spoke protein 9 | protein | 254 | 24% helix, 31% strand | Q27YU5 |
| B | Radial spoke protein 9 | protein | 251 | 23% helix, 34% strand | Q27YU5 |
| C | Flagellar radial spoke protein 4 | protein | 280 | 23% helix, 22% strand | Q01656 |
| D | Flagellar radial spoke protein 6 | protein | 339 | 22% helix, 19% strand | Q01657 |
| F | Flagellar radial spoke protein 6 | protein | 8 | 0% helix, 0% strand | — |
| G | Flagellar radial spoke protein 10 | protein | 6 | 0% helix, 50% strand | — |
| E | Radial spoke protein 10 | protein | 176 | 0% helix, 59% strand | Q27YU4 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.89 | 0.93 | 120 | empty |
| 2 | 501 | 0.87 | 0.93 | 69 | empty |
| 3 | 693 | 0.83 | 0.87 | 78 | empty |
| 4 | 617 | 0.81 | 0.86 | 66 | empty |
| 5 | 328 | 0.75 | 0.86 | 53 | empty |
Interfaces
11 interfaces between chains.
- B–D · 1669 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 1463 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 985 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 959 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 851 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7JR9 · Chlamydomonas reinhardtii radial spoke minimal head complex · the same entry in another collection · chain E against E, TM-score 1.00
- Q01656 · AlphaFold monomer V2.0 prediction for flagellar radial spoke protein 4 (Q01656) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q01657 · AlphaFold monomer V2.0 prediction for flagellar radial spoke protein 6 (Q01657) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q27YU5
- Every structure of UniProt Q01656
- Every structure of UniProt Q01657
- Every structure of UniProt Q27YU4
- Elsewhere: RCSB PDB 7JR9 · PDBe 7JR9 · UniProt Q27YU5 · UniProt Q01656 · UniProt Q01657 · UniProt Q27YU4
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