MolNFT v1 · #17893 · protein

Crystal structure of an inward rectifier potassium channel

1P7B · Integral membrane channel and cytosolic domains: “Crystal structure of an inward rectifier potassium channel”. X-ray diffraction, 1 ligand (K), 7 pockets (best druggability 0.70). MolNFT v1 #17893 on GenesisL1: 3D structure, binding…

PDB: 1P7B
Type: protein
Length: 516 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integral membrane channel and cytosolic domains
UniProt: P83698
Ligands: K
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Integral membrane channel and cytosolic domains	protein	258	31% helix, 22% strand	P83698

Ligands and binding sites

K · Potassium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	527	0.70	0.79	51	empty
2	218	0.63	0.82	29	empty
3	440	0.61	0.75	37	empty
4	185	0.49	0.77	31	empty
5	53	0.44	0.84	18	empty

Interfaces

1 interface between chains.

A–B · 2334 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

1P7B · Crystal structure of an inward rectifier potassium channel · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83698
Elsewhere: RCSB PDB 1P7B · PDBe 1P7B · UniProt P83698

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