MolNFT v1 · #178801 · protein

Crystal structure of aminoglycoside resistance enzyme apma, apoenzyme

7JM0 · Aminocyclitol acetyltransferase apma: “Crystal structure of aminoglycoside resistance enzyme apma, apoenzyme”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.72). MolNFT v1 #178801 on GenesisL1: 3D structure…

PDB: 7JM0
Type: protein
Length: 821 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminocyclitol acetyltransferase apma
UniProt: A0A1D0AST6
Ligands: SO4
Pockets: 8 · best druggability 0.72

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aminocyclitol acetyltransferase apma	protein	273	33% helix, 21% strand	A0A1D0AST6
B	Aminocyclitol acetyltransferase apma	protein	274	32% helix, 21% strand	A0A1D0AST6
C	Aminocyclitol acetyltransferase apma	protein	274	33% helix, 21% strand	A0A1D0AST6

Ligands and binding sites

SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	339	0.72	0.84	54	empty
2	559	0.65	0.76	51	empty
3	241	0.65	0.82	27	empty
4	566	0.61	0.74	51	empty
5	188	0.58	0.81	25	empty

Interfaces

3 interfaces between chains.

A–C · 1796 Å² buried · 33 hydrogen bonds · protein-protein
B–C · 1711 Å² buried · 30 hydrogen bonds · protein-protein
A–B · 1625 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

7JM0 · Crystal structure of aminoglycoside resistance enzyme ApmA, apoenzyme · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1D0AST6
Elsewhere: RCSB PDB 7JM0 · PDBe 7JM0 · UniProt A0A1D0AST6

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