MolNFT v1 · #178717 · protein

Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1

7JJH · Transcription initiation factor tfiid subunit 1: “Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #178717 on GenesisL1: 3D structure…

PDB: 7JJH
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid subunit 1
EC: 2.3.1.48, 2.7.11.1
UniProt: P21675
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1)	protein	253	67% helix, 0% strand	P21675

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.51	0.81	18	EDO
2	85	0.45	0.80	20	empty

Compared structures

7JJH · Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1 · the same entry in another collection · chain A against A, TM-score 1.00
P21675 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21675
Elsewhere: RCSB PDB 7JJH · PDBe 7JJH · UniProt P21675

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