MolNFT v1 · #178637 · protein

Cardiac actomyosin complex

7JH7 · Actin, alpha cardiac muscle 1: “Cardiac actomyosin complex”. Electron microscopy, 2 ligands (ADP, MG), 20 pockets (best druggability 0.83). MolNFT v1 #178637 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JH7
Type: protein
Length: 4,351 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin, alpha cardiac muscle 1; Myosin-7; Tropomyosin
UniProt: B6VNT8, P79293
Ligands: ADP, MG
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 3 distinct chains · 46% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, E, D	Actin, alpha cardiac muscle 1	protein	371	38% helix, 16% strand	B6VNT8
F, G, H	Myosin-7	protein	742	41% helix, 14% strand	P79293
I, J	Tropomyosin	protein	135	99% helix, 0% strand	—

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 5 copies · chains A, B, C, E, D
MG · Magnesium ion · metal · 5 copies · chains A, B, C, E, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1020	0.83	0.84	105	empty
2	845	0.82	0.84	87	empty
3	485	0.81	0.88	53	empty
4	501	0.80	0.87	55	empty
5	482	0.80	0.88	55	empty

Interfaces

22 interfaces between chains.

I–J · 1485 Å² buried · 0 hydrogen bonds · protein-protein
A–B · 1246 Å² buried · 12 hydrogen bonds · protein-protein
B–G · 1242 Å² buried · 5 hydrogen bonds · protein-protein
A–F · 1241 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 1233 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7JH7 · cardiac actomyosin complex · the same entry in another collection · chain J against J, TM-score 1.00
P79293 · AlphaFold monomer V2.0 prediction for myosin-7 (P79293) · a predicted model of the same protein · chain F against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B6VNT8
Every structure of UniProt P79293
Elsewhere: RCSB PDB 7JH7 · PDBe 7JH7 · UniProt B6VNT8 · UniProt P79293

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