MolNFT v1 · #178612 · protein
Cryo-EM structure of P. falciparum VAR2CSA FCR3 domains DBL5 and DBL6 at 4.69 a
7JGF · Erythrocyte membrane protein 1: “Cryo-EM structure of P. falciparum VAR2CSA FCR3 domains DBL5 and DBL6 at 4.69 a”. Electron microscopy, 9 pockets (best druggability 0.83). MolNFT v1 #178612 on GenesisL1: 3D structure, binding sites…
- PDB
- 7JGF
- Type
- protein
- Length
- 532 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Erythrocyte membrane protein 1
- UniProt
- Q6UDW7
- Pockets
- 9 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 58% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Erythrocyte membrane protein 1 | protein | 532 | 58% helix, 1% strand | Q6UDW7 |
Pockets
9 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 975 | 0.83 | 0.84 | 94 | empty |
| 2 | 763 | 0.80 | 0.83 | 73 | empty |
| 3 | 1075 | 0.75 | 0.78 | 96 | empty |
| 4 | 215 | 0.72 | 0.88 | 25 | empty |
| 5 | 192 | 0.69 | 0.87 | 25 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7JGF · Cryo-EM structure of P. falciparum VAR2CSA FCR3 domains DBL5 and DBL6 at 4.69 A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UDW7
- Elsewhere: RCSB PDB 7JGF · PDBe 7JGF · UniProt Q6UDW7
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