MolNFT v1 · #178611 · protein
Cryo-EM structure of P. falciparum VAR2CSA FCR3 core at 4 a
7JGE · Erythrocyte membrane protein 1: “Cryo-EM structure of P. falciparum VAR2CSA FCR3 core at 4 a”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #178611 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JGE
- Type
- protein
- Length
- 1,437 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Erythrocyte membrane protein 1
- UniProt
- Q6UDW7
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 53% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Erythrocyte membrane protein 1 | protein | 1437 | 53% helix, 1% strand | Q6UDW7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1047 | 0.85 | 0.86 | 103 | empty |
| 2 | 82 | 0.73 | 0.96 | 20 | empty |
| 3 | 287 | 0.72 | 0.86 | 51 | empty |
| 4 | 404 | 0.72 | 0.83 | 47 | empty |
| 5 | 398 | 0.71 | 0.82 | 34 | empty |
Modifications
Observed in the structure: 27 disulfide (disulfide).
Compared structures
- 7JGE · Cryo-EM structure of P. falciparum VAR2CSA FCR3 core at 4 A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6UDW7
- Elsewhere: RCSB PDB 7JGE · PDBe 7JGE · UniProt Q6UDW7
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