MolNFT v1 · #178462 · protein
Structure of the human meckelin
7FH1: “Structure of the human meckelin”. Electron microscopy, 2 ligands (NAG, BMA), 20 pockets (best druggability 0.76). MolNFT v1 #178462 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FH1
- Type
- protein
- Length
- 1,748 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Meckelin
- UniProt
- Q5HYA8
- Ligands
- NAG, BMA
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 35% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Meckelin | protein | 874 | 35% helix, 15% strand | Q5HYA8 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 16 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 487 | 0.76 | 0.84 | 64 | empty |
| 2 | 475 | 0.72 | 0.81 | 59 | empty |
| 3 | 536 | 0.68 | 0.78 | 66 | empty |
| 4 | 573 | 0.66 | 0.76 | 58 | empty |
| 5 | 483 | 0.66 | 0.78 | 66 | empty |
Interfaces
1 interface between chains.
- A–B · 5031 Ų buried · 42 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5HYA8
- Elsewhere: RCSB PDB 7FH1 · PDBe 7FH1 · UniProt Q5HYA8
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