MolNFT v1 · #178416 · protein
Diarylpentanoid-producing polyketide synthase (N199L mutant)
7FFH · Type III polyketide synthase: “Diarylpentanoid-producing polyketide synthase (N199L mutant)”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #178416 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FFH
- Type
- protein
- Length
- 771 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type III polyketide synthase
- UniProt
- A0A385MEG6
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type III polyketide synthase | protein | 385 | 39% helix, 23% strand | A0A385MEG6 |
| B | Type III polyketide synthase | protein | 386 | 38% helix, 23% strand | A0A385MEG6 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 279 | 0.74 | 0.87 | 44 | empty |
| 2 | 309 | 0.73 | 0.85 | 37 | empty |
| 3 | 585 | 0.72 | 0.80 | 50 | empty |
| 4 | 283 | 0.49 | 0.73 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 359 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7FFH · Diarylpentanoid-producing polyketide synthase (N199L mutant) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A385MEG6
- Elsewhere: RCSB PDB 7FFH · PDBe 7FFH · UniProt A0A385MEG6
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