MolNFT v1 · #178408 · protein
The crystal structure of clostridium cellulolyticum laci family transcriptional regulator CCEL_1438
7FF4 · Transcriptional regulator, laci family: “The crystal structure of clostridium cellulolyticum laci family transcriptional regulator CCEL_1438”. X-ray diffraction, 17 pockets (best druggability 0.73). MolNFT v1 #178408 on GenesisL1…
- PDB
- 7FF4
- Type
- protein
- Length
- 1,117 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator, laci family
- UniProt
- B8I1W6
- Pockets
- 17 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Transcriptional regulator, laci family | protein | 280 | 42% helix, 19% strand | B8I1W6 |
| B | Transcriptional regulator, laci family | protein | 278 | 42% helix, 19% strand | B8I1W6 |
| C | Transcriptional regulator, laci family | protein | 279 | 42% helix, 19% strand | B8I1W6 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 629 | 0.73 | 0.80 | 56 | empty |
| 2 | 699 | 0.73 | 0.79 | 51 | empty |
| 3 | 599 | 0.72 | 0.80 | 75 | empty |
| 4 | 538 | 0.68 | 0.78 | 49 | empty |
| 5 | 560 | 0.66 | 0.77 | 47 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2008 Ų buried · 27 hydrogen bonds · protein-protein
- A–D · 516 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 472 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 249 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 241 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7FF4 · The crystal structure of Clostridium cellulolyticum LacI family transcriptional regulator… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8I1W6
- Elsewhere: RCSB PDB 7FF4 · PDBe 7FF4 · UniProt B8I1W6
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