MolNFT v1 · #178401 · protein
Cryo-EM structure of apo bsclpp at pH 4.2
7FES · ATP-dependent clp protease proteolytic subunit: “Cryo-EM structure of apo bsclpp at pH 4.2”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #178401 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FES
- Type
- protein
- Length
- 2,198 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease proteolytic subunit
- EC
- 3.4.21.92
- UniProt
- P80244
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 41% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 157 | 41% helix, 4% strand | P80244 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.77 | 0.94 | 36 | empty |
| 2 | 443 | 0.77 | 0.85 | 81 | empty |
| 3 | 582 | 0.76 | 0.82 | 90 | empty |
| 4 | 117 | 0.74 | 0.93 | 35 | empty |
| 5 | 135 | 0.73 | 0.92 | 39 | empty |
Interfaces
28 interfaces between chains.
- K–L · 851 Ų buried · 1 hydrogen bond · protein-protein
- H–N · 788 Ų buried · 1 hydrogen bond · protein-protein
- J–K · 782 Ų buried · 2 hydrogen bonds · protein-protein
- E–F · 780 Ų buried · 6 hydrogen bonds · protein-protein
- A–G · 764 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7FES · Cryo-EM structure of apo BsClpP at pH 4.2 · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P80244
- Elsewhere: RCSB PDB 7FES · PDBe 7FES · UniProt P80244
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