MolNFT v1 · #178279 · protein
VAR2CSA 3D7 ectodomain core region
7FAS · Erythrocyte membrane protein 1, PFEMP1: “VAR2CSA 3D7 ectodomain core region”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #178279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FAS
- Type
- protein
- Length
- 1,229 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Erythrocyte membrane protein 1, PFEMP1
- UniProt
- Q8I639
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 55% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Erythrocyte membrane protein 1, PFEMP1 | protein | 1229 | 55% helix, 2% strand | Q8I639 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 938 | 0.83 | 0.84 | 122 | empty |
| 2 | 497 | 0.77 | 0.85 | 45 | empty |
| 3 | 578 | 0.70 | 0.78 | 46 | empty |
| 4 | 255 | 0.68 | 0.84 | 32 | empty |
| 5 | 550 | 0.66 | 0.77 | 62 | empty |
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 7FAS · VAR2CSA 3D7 ectodomain core region · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I639
- Elsewhere: RCSB PDB 7FAS · PDBe 7FAS · UniProt Q8I639
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