MolNFT v1 · #178226 · protein
Roadblock from thorarchaeota SMTZ1-45
7F8M · ROBL_LC7 domain-containing protein: “Roadblock from thorarchaeota SMTZ1-45”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #178226 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7F8M
- Type
- protein
- Length
- 702 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ROBL_LC7 domain-containing protein
- UniProt
- A0A135VIJ8
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | ROBL_LC7 domain-containing protein | protein | 117 | 44% helix, 29% strand | A0A135VIJ8 |
| B | ROBL_LC7 domain-containing protein | protein | 120 | 43% helix, 26% strand | A0A135VIJ8 |
| D, E, F | ROBL_LC7 domain-containing protein | protein | 116 | 36% helix, 28% strand | A0A135VIJ8 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1152 | 0.73 | 0.76 | 136 | empty |
| 2 | 125 | 0.62 | 0.86 | 22 | empty |
| 3 | 375 | 0.59 | 0.76 | 49 | empty |
| 4 | 64 | 0.40 | 0.80 | 18 | empty |
| 5 | 54 | 0.37 | 0.80 | 17 | empty |
Interfaces
8 interfaces between chains.
- E–F · 1530 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1515 Ų buried · 30 hydrogen bonds · protein-protein
- A–D · 1507 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 445 Ų buried · 2 hydrogen bonds · protein-protein
- D–E · 381 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7F8M · Roadblock from Thorarchaeota SMTZ1-45 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A135VIJ8
- Elsewhere: RCSB PDB 7F8M · PDBe 7F8M · UniProt A0A135VIJ8
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