MolNFT v1 · #178216 · protein

Crystal structure of rRNA methyltransferase ERM38 in complex with SAM

7F8B · ERM(38): “Crystal structure of rRNA methyltransferase ERM38 in complex with SAM”. X-ray diffraction, 1 ligand (SAM), 1 pocket (best druggability 0.66). MolNFT v1 #178216 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7F8B
Type: protein
Length: 245 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ERM(38)
UniProt: Q79N53
Ligands: SAM
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ERM(38)	protein	245	40% helix, 20% strand	Q79N53

Ligands and binding sites

SAM · S-adenosylmethionine · ligand · chains A
SIN · Succinic acid · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.66	0.86	29	SAM

Compared structures

7F8B · Crystal structure of rRNA methyltransferase Erm38 in complex with SAM · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q79N53
Elsewhere: RCSB PDB 7F8B · PDBe 7F8B · UniProt Q79N53

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