MolNFT v1 · #178214 · protein

Crystal structure of GH19 chitinase lacking the third loop structure

7F88 · Chitinase a: “Crystal structure of GH19 chitinase lacking the third loop structure”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #178214 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7F88
Type: protein
Length: 562 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chitinase a
UniProt: A9ZSX9
Pockets: 5 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 55% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chitinase a	protein	189	56% helix, 2% strand	A9ZSX9
B	Chitinase a	protein	185	57% helix, 2% strand	A9ZSX9
C	Chitinase a	protein	188	53% helix, 2% strand	A9ZSX9

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	867	0.78	0.81	72	empty
2	509	0.77	0.84	62	empty
3	140	0.51	0.79	22	empty
4	75	0.39	0.78	19	empty
5	94	0.35	0.74	21	empty

Interfaces

3 interfaces between chains.

A–B · 945 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 328 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 294 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7F88 · Crystal structure of GH19 chitinase lacking the third loop structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9ZSX9
Elsewhere: RCSB PDB 7F88 · PDBe 7F88 · UniProt A9ZSX9

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