MolNFT v1 · #178141 · protein
Drosophila P5CS filament with glutamate and atpgammas
7F5U · Delta-1-pyrroline-5-carboxylate synthase: “Drosophila P5CS filament with glutamate and atpgammas”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #178141 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7F5U
- Type
- protein
- Length
- 2,740 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Delta-1-pyrroline-5-carboxylate synthase
- EC
- 2.7.2.11, 1.2.1.41
- UniProt
- Q9VNW6
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 43% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41) | protein | 685 | 43% helix, 13% strand | Q9VNW6 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 950 | 0.84 | 0.85 | 91 | empty |
| 2 | 1138 | 0.83 | 0.84 | 118 | empty |
| 3 | 1140 | 0.83 | 0.84 | 124 | empty |
| 4 | 820 | 0.77 | 0.81 | 57 | empty |
| 5 | 832 | 0.76 | 0.80 | 60 | empty |
Interfaces
6 interfaces between chains.
- A–C · 3628 Ų buried · 50 hydrogen bonds · protein-protein
- B–D · 3628 Ų buried · 50 hydrogen bonds · protein-protein
- B–C · 1356 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 1348 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 103 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7F5U · Drosophila P5CS filament with glutamate and ATPgammaS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VNW6
- Elsewhere: RCSB PDB 7F5U · PDBe 7F5U · UniProt Q9VNW6
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