MolNFT v1 · #178105 · protein

Crystal structure of MTA1

7F4R · Mt-A70 family protein: “Crystal structure of MTA1”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #178105 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7F4R
Type: protein
Length: 702 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mt-A70 family protein
UniProt: Q22GC0
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 26% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mt-A70 family protein	protein	178	26% helix, 27% strand	Q22GC0
B	Mt-A70 family protein	protein	174	27% helix, 28% strand	Q22GC0
C	Mt-A70 family protein	protein	177	26% helix, 28% strand	Q22GC0
D	Mt-A70 family protein	protein	173	26% helix, 29% strand	Q22GC0

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1099	0.78	0.80	81	empty
2	588	0.70	0.79	35	empty
3	130	0.43	0.76	22	empty
4	104	0.35	0.73	24	empty
5	103	0.34	0.73	20	empty

Interfaces

4 interfaces between chains.

A–B · 1690 Å² buried · 30 hydrogen bonds · protein-protein
C–D · 1659 Å² buried · 25 hydrogen bonds · protein-protein
B–D · 1504 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 1503 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

7F4R · Crystal structure of MTA1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q22GC0
Elsewhere: RCSB PDB 7F4R · PDBe 7F4R · UniProt Q22GC0

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