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MolNFT v1 · #1781 · protein + DNA

Structures of sap-1 bound to DNA sequences from the E74 and C-fos promoters provide insights into how ets proteins discriminate between related DNA targets

1BC8 · DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'): “Structures of sap-1 bound to DNA sequences from the E74 and C-fos promoters provide insights into how ets…”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #1781 on GenesisL1: 3D…

PDB
1BC8
Type
protein + DNA
Length
113 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'); DNA…
UniProt
P28324
Ligands
ZN

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 13% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3')dna10——
BDNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3')dna10——
CProtein (sap-1 ets domain)protein9343% helix, 13% strandP28324

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

  • B–C · 516 Ų buried · 9 hydrogen bonds · protein-nucleic
  • A–C · 437 Ų buried · 11 hydrogen bonds · protein-nucleic
  • A–B · 405 Ų buried · 33 hydrogen bonds · nucleic-nucleic

Compared structures

  • 1BC8 · Structures of sap-1 bound to DNA sequences from the E74 and C-fos promoters provide… · the same entry in another collection · chain A against A, TM-score 1.00
  • P28324 · AlphaFold monomer V2.0 prediction for ets domain-containing protein elk-4 (P28324) · a predicted model of the same protein · chain C against A, TM-score 0.96

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