MolNFT v1 · #178078 · protein
Lysophospholipid acyltransferase LPCAT3 in complex with lysophosphatidylcholine
7F3X: “Lysophospholipid acyltransferase LPCAT3 in complex with lysophosphatidylcholine”. Electron microscopy, 1 ligand (LAP), 13 pockets (best druggability 0.84). MolNFT v1 #178078 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7F3X
- Type
- protein
- Length
- 898 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LPCAT3
- UniProt
- A0A1L1RNG8
- Ligands
- LAP
- Pockets
- 13 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 62% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | LPCAT3 | protein | 449 | 62% helix, 1% strand | A0A1L1RNG8 |
Ligands and binding sites
- LAP · [2-((1-oxododecanoxy-(2-hydroxy-3-propanyl))-phosphonate-oxy)-ethyl]-trimethylammonium · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.84 | 0.85 | 85 | LAP |
| 2 | 1141 | 0.84 | 0.84 | 84 | LAP |
| 3 | 94 | 0.74 | 0.95 | 22 | empty |
| 4 | 199 | 0.70 | 0.87 | 27 | empty |
| 5 | 101 | 0.70 | 0.92 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 167 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7F3X · Lysophospholipid acyltransferase LPCAT3 in complex with lysophosphatidylcholine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L1RNG8
- Elsewhere: RCSB PDB 7F3X · PDBe 7F3X · UniProt A0A1L1RNG8
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