MolNFT v1 · #178047 · protein

Urate oxidase from thermobispora bispora in apo form

7F2V · Uricase: “Urate oxidase from thermobispora bispora in apo form”. X-ray diffraction, 1 ligand (SO4), 7 pockets (best druggability 0.57). MolNFT v1 #178047 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7F2V
Type: protein
Length: 600 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uricase
EC: 1.7.3.3
UniProt: D6Y599
Ligands: SO4
Pockets: 7 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Uricase (EC 1.7.3.3)	protein	300	26% helix, 37% strand	D6Y599

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B
DMS · Dimethyl sulfoxide · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	330	0.57	0.76	41	empty
2	164	0.48	0.77	25	empty
3	134	0.46	0.77	25	DMS
4	150	0.45	0.76	22	DMS
5	92	0.43	0.79	18	SO4

Interfaces

1 interface between chains.

A–B · 2612 Å² buried · 37 hydrogen bonds · protein-protein

Compared structures

7F2V · Urate oxidase from Thermobispora bispora in apo form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D6Y599
Elsewhere: RCSB PDB 7F2V · PDBe 7F2V · UniProt D6Y599

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