MolNFT v1 · #178023 · protein
L-lactate oxidase with pyruvate
7F22: “L-lactate oxidase with pyruvate”. X-ray diffraction, 2 ligands (FMN, PYR), 10 pockets (best druggability 0.81). MolNFT v1 #178023 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7F22
- Type
- protein
- Length
- 736 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate oxidase
- Ligands
- FMN, PYR
- Pockets
- 10 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | L-lactate oxidase | protein | 368 | 44% helix, 13% strand | — |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- PYR · Pyruvic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.81 | 0.97 | 32 | FMN, PYR |
| 2 | 148 | 0.80 | 0.97 | 30 | FMN, PYR |
| 3 | 313 | 0.65 | 0.81 | 42 | empty |
| 4 | 183 | 0.65 | 0.85 | 24 | empty |
| 5 | 68 | 0.43 | 0.81 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 935 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7F22 · L-lactate oxidase with pyruvate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7F22 · PDBe 7F22
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