MolNFT v1 · #178007 · protein + RNA

Marburg virus nucleoprotein-RNA complex

7F1M: “Marburg virus nucleoprotein-RNA complex”. Electron microscopy, 9 pockets (best druggability 0.66). MolNFT v1 #178007 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7F1M
Type: protein + RNA
Length: 800 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoprotein; RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
UniProt: Q1PD53
Pockets: 9 · best druggability 0.66

Structure

electron microscopy · 2 distinct chains · 61% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Nucleoprotein	protein	394	61% helix, 5% strand	Q1PD53
R, S	RNA (5'-R(PUPUPUPUPUPU)-3')	rna	6	—	—

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.66	0.76	54	empty
2	63	0.56	0.89	19	empty
3	198	0.51	0.77	19	empty
4	207	0.49	0.76	24	empty
5	142	0.45	0.76	17	empty

Interfaces

3 interfaces between chains.

A–R · 774 Å² buried · 12 hydrogen bonds · protein-nucleic
B–S · 769 Å² buried · 9 hydrogen bonds · protein-nucleic
A–B · 271 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7F1M · Marburg virus nucleoprotein-RNA complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1PD53
Elsewhere: RCSB PDB 7F1M · PDBe 7F1M · UniProt Q1PD53

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.