MolNFT v1 · #177979 · protein
A crystal structure of alphavirus nonstructural protein 4 (NSP4) reveals an intrinsically 1DYNAMIC RNA-dependent RNA polymerase
7F0S · RNA-directed RNA polymerase NSP4: “A crystal structure of alphavirus nonstructural protein 4 (NSP4) reveals an intrinsically 1DYNAMIC…”. X-ray diffraction, 5 pockets (best druggability 0.62). MolNFT v1 #177979 on GenesisL1: 3D…
- PDB
- 7F0S
- Type
- protein
- Length
- 419 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase NSP4
- EC
- 2.7.7.48
- UniProt
- P13888
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase NSP4 (EC 2.7.7.48) | protein | 419 | 47% helix, 12% strand | P13888 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.62 | 0.86 | 23 | empty |
| 2 | 219 | 0.53 | 0.77 | 29 | empty |
| 3 | 237 | 0.48 | 0.73 | 35 | empty |
| 4 | 208 | 0.47 | 0.74 | 34 | empty |
| 5 | 84 | 0.39 | 0.77 | 20 | empty |
Compared structures
- 7F0S · A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13888
- Elsewhere: RCSB PDB 7F0S · PDBe 7F0S · UniProt P13888
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