MolNFT v1 · #177967 · protein
Crystal structure of ENPKS2
7F0E: “Crystal structure of ENPKS2”. X-ray diffraction, 16 pockets (best druggability 0.78). MolNFT v1 #177967 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7F0E
- Type
- protein
- Length
- 1,501 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENPKS2
- Pockets
- 16 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ENPKS2 | protein | 374 | 41% helix, 23% strand | — |
| B | ENPKS2 | protein | 376 | 40% helix, 24% strand | — |
| C | ENPKS2 | protein | 374 | 42% helix, 25% strand | — |
| D | ENPKS2 | protein | 377 | 43% helix, 23% strand | — |
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 811 | 0.78 | 0.82 | 78 | empty |
| 2 | 239 | 0.72 | 0.87 | 33 | empty |
| 3 | 243 | 0.72 | 0.86 | 43 | empty |
| 4 | 243 | 0.67 | 0.83 | 32 | empty |
| 5 | 245 | 0.67 | 0.83 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–D · 2489 Ų buried · 46 hydrogen bonds · protein-protein
- B–C · 2480 Ų buried · 47 hydrogen bonds · protein-protein
- C–D · 225 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7F0E · Crystal Structure of EnPKS2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7F0E · PDBe 7F0E
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