MolNFT v1 · #177925 · protein
Crystal structure of leech hyaluronidase
7EYO · Hyaluronoglucuronidase: “Crystal structure of leech hyaluronidase”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.58). MolNFT v1 #177925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EYO
- Type
- protein
- Length
- 486 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hyaluronoglucuronidase
- EC
- 3.2.1.36
- UniProt
- X4Y2L4
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hyaluronoglucuronidase (EC 3.2.1.36) | protein | 486 | 28% helix, 28% strand | X4Y2L4 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.58 | 0.77 | 38 | GOL |
| 2 | 293 | 0.58 | 0.78 | 40 | empty |
| 3 | 118 | 0.42 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 2 glycan, 1 disulfide (N-glycosylation, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt X4Y2L4
- Elsewhere: RCSB PDB 7EYO · PDBe 7EYO · UniProt X4Y2L4
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