MolNFT v1 · #177917 · protein
Crystal structure of tau and acetylated tau peptide antigen
7EYC · Antibody, light chain: “Crystal structure of tau and acetylated tau peptide antigen”. X-ray diffraction, 11 pockets (best druggability 0.80). MolNFT v1 #177917 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EYC
- Type
- protein
- Length
- 876 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody, light chain; Antibody, heavy chain; Acetylated tau peptide
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, B | Antibody, light chain | protein | 217 | 6% helix, 51% strand | — |
| H | Antibody, heavy chain | protein | 213 | 8% helix, 51% strand | — |
| A | Antibody, heavy chain | protein | 214 | 11% helix, 51% strand | — |
| P | Acetylated tau peptide | protein | 7 | 0% helix, 0% strand | — |
| Q | Acetylated tau peptide | protein | 8 | 0% helix, 0% strand | — |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 910 | 0.80 | 0.82 | 75 | empty |
| 2 | 85 | 0.57 | 0.87 | 19 | empty |
| 3 | 368 | 0.55 | 0.74 | 34 | empty |
| 4 | 155 | 0.53 | 0.80 | 30 | empty |
| 5 | 69 | 0.45 | 0.82 | 20 | empty |
Interfaces
11 interfaces between chains.
- B–A · 1667 Ų buried · 15 hydrogen bonds · protein-protein
- L–H · 1644 Ų buried · 14 hydrogen bonds · protein-protein
- H–A · 655 Ų buried · 13 hydrogen bonds · protein-protein
- L–P · 457 Ų buried · 8 hydrogen bonds · protein-protein
- B–Q · 449 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 2 modified (disulfide, acetylation).
Compared structures
- 7EYC · Crystal structure of Tau and acetylated tau peptide antigen · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7EYC · PDBe 7EYC
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