MolNFT v1 · #177892 · protein
Dfga-dfgb complex apo 2.4 ångström
7EXB · Sugar phosphate ISOMERASE/EPIMERASE: “Dfga-dfgb complex apo 2.4 ångström”. X-ray diffraction, 2 ligands (MN, SO4), 5 pockets (best druggability 0.76). MolNFT v1 #177892 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EXB
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sugar phosphate ISOMERASE/EPIMERASE; Dfgb
- UniProt
- I5AX50, I5AX49
- Ligands
- MN, SO4
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sugar phosphate ISOMERASE/EPIMERASE | protein | 290 | 42% helix, 18% strand | I5AX50 |
| B | Dfgb | protein | 151 | 13% helix, 38% strand | I5AX49 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 667 | 0.76 | 0.81 | 57 | empty |
| 2 | 178 | 0.58 | 0.81 | 38 | empty |
| 3 | 141 | 0.57 | 0.83 | 32 | empty |
| 4 | 121 | 0.43 | 0.76 | 26 | empty |
| 5 | 112 | 0.37 | 0.73 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1203 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7EXB · DfgA-DfgB complex apo 2.4 angstrom · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I5AX50
- Every structure of UniProt I5AX49
- Elsewhere: RCSB PDB 7EXB · PDBe 7EXB · UniProt I5AX50 · UniProt I5AX49
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