MolNFT v1 · #177884 · protein

Crystal structure of ebinur lake virus cap snatching endonuclease (Y109A mutant)

7EX1 · Replicase: “Crystal structure of ebinur lake virus cap snatching endonuclease (Y109A mutant)”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.34). MolNFT v1 #177884 on GenesisL1: 3D structure, binding sites and…

PDB: 7EX1
Type: protein
Length: 340 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replicase
EC: 2.7.7.48
UniProt: A0A059WLS9
Ligands: CL
Pockets: 4 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replicase (EC 2.7.7.48)	protein	171	52% helix, 15% strand	A0A059WLS9
B	Replicase (EC 2.7.7.48)	protein	169	51% helix, 14% strand	A0A059WLS9

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.34	0.75	20	CL
2	69	0.29	0.73	18	empty
3	52	0.29	0.75	14	empty
4	57	0.29	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 212 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7EX1 · Crystal structure of Ebinur Lake virus cap snatching endonuclease (Y109A mutant) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A059WLS9
Elsewhere: RCSB PDB 7EX1 · PDBe 7EX1 · UniProt A0A059WLS9

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