MolNFT v1 · #177765 · protein
Co-crystal structure of human nicotinamide N-methyltransferase (nnmt) with tricyclic small molecule inhibitor jbsnf-000028
7ET7: “Co-crystal structure of human nicotinamide N-methyltransferase (nnmt) with tricyclic small molecule inhibitor…”. X-ray diffraction, 1 ligand (JCU). MolNFT v1 #177765 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ET7
- Type
- protein
- Length
- 1,029 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P40261
- Ligands
- JCU
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | — | protein | 257 | — | P40261 |
| D | — | protein | 258 | — | P40261 |
Ligands and binding sites
- JCU · 10-methyl-1,10-diazatricyclo[6.3.1.0^{4,12}]dodeca-4,6, 8(12)-trien-11-imine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7ET7 · Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with tricyclic… · the same entry in another collection · chain D against D, TM-score 1.00
- P40261 · AlphaFold monomer V2.0 prediction for nicotinamide N-methyltransferase (P40261) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40261
- Elsewhere: RCSB PDB 7ET7 · PDBe 7ET7 · UniProt P40261
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.