MolNFT v1 · #177724 · protein

The regulatory domain of yeie, a sulfite sensing lysr-type transcriptional regulator from cronobacter sakazakii (ligand-free form)

7ERQ · Lysr family transcriptional regulator: “The regulatory domain of yeie, a sulfite sensing lysr-type transcriptional regulator from cronobacter…”. X-ray diffraction, 4 pockets (best druggability 0.57). MolNFT v1 #177724 on GenesisL1…

PDB: 7ERQ
Type: protein
Length: 402 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysr family transcriptional regulator
UniProt: H9BVC9
Pockets: 4 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysr family transcriptional regulator	protein	199	38% helix, 30% strand	H9BVC9
B	Lysr family transcriptional regulator	protein	203	36% helix, 30% strand	H9BVC9

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	331	0.57	0.77	51	empty
2	60	0.35	0.78	15	empty
3	60	0.29	0.74	16	empty
4	54	0.27	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 1188 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

7ERQ · The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H9BVC9
Elsewhere: RCSB PDB 7ERQ · PDBe 7ERQ · UniProt H9BVC9

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