MolNFT v1 · #177688 · protein
Crystal structure of arabidopsis GUN2/HO1 in complex with heme
7EQH · Heme oxygenase 1, chloroplastic: “Crystal structure of arabidopsis GUN2/HO1 in complex with heme”. X-ray diffraction, 1 ligand (HEM), 3 pockets (best druggability 0.79). MolNFT v1 #177688 on GenesisL1: 3D structure, binding sites…
- PDB
- 7EQH
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heme oxygenase 1, chloroplastic
- EC
- 1.14.14.18
- UniProt
- O48782
- Ligands
- HEM
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heme oxygenase 1, chloroplastic (EC 1.14.14.18) | protein | 212 | 68% helix, 1% strand | O48782 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 406 | 0.79 | 0.87 | 45 | HEM |
| 2 | 383 | 0.78 | 0.87 | 49 | HEM |
| 3 | 328 | 0.57 | 0.76 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 219 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7EQH · Crystal structure of Arabidopsis GUN2/HO1 in complex with heme · the same entry in another collection · chain A against A, TM-score 1.00
- O48782 · AlphaFold monomer V2.0 prediction for heme oxygenase 1, chloroplastic (O48782) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O48782
- Elsewhere: RCSB PDB 7EQH · PDBe 7EQH · UniProt O48782
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.