MolNFT v1 · #177673 · protein

Crystal structure of tigecycline degrading monooxygenase TET(X4)

7EPV · Flavin-dependent monooxygenase: “Crystal structure of tigecycline degrading monooxygenase TET(X4)”. X-ray diffraction, 1 ligand (FDA), 1 pocket (best druggability 0.79). MolNFT v1 #177673 on GenesisL1: 3D structure, binding sites…

PDB: 7EPV
Type: protein
Length: 369 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flavin-dependent monooxygenase
EC: 1.14.13.-
UniProt: A0A3T0V9Y5
Ligands: FDA
Pockets: 1 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Flavin-dependent monooxygenase (EC 1.14.13.-)	protein	369	33% helix, 25% strand	A0A3T0V9Y5

Ligands and binding sites

FDA · Dihydroflavine-adenine dinucleotide · ligand · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1093	0.79	0.80	88	FDA

Compared structures

7EPV · Crystal structure of tigecycline degrading monooxygenase Tet(X4) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3T0V9Y5
Elsewhere: RCSB PDB 7EPV · PDBe 7EPV · UniProt A0A3T0V9Y5

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