MolNFT v1 · #177650 · protein

Engineered hepatitis B virus core antigen T=4

7EP6 · Capsid PROTEIN,IMMUNOGLOBULIN G-binding protein a: “Engineered hepatitis B virus core antigen T=4”. Electron microscopy, 10 pockets (best druggability 0.73). MolNFT v1 #177650 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7EP6
Type: protein
Length: 564 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid PROTEIN,IMMUNOGLOBULIN G-binding protein a
UniProt: P69706
Pockets: 10 · best druggability 0.73

Structure

electron microscopy · 1 distinct chain · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Capsid PROTEIN,IMMUNOGLOBULIN G-binding protein a	protein	141	65% helix, 0% strand	P69706

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	529	0.73	0.81	70	empty
2	129	0.72	0.91	25	empty
3	247	0.69	0.84	35	empty
4	206	0.67	0.85	38	empty
5	66	0.65	0.93	18	empty

Interfaces

3 interfaces between chains.

A–B · 1828 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 1793 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 641 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7EP6 · Engineered Hepatitis B virus core antigen T=4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P69706
Elsewhere: RCSB PDB 7EP6 · PDBe 7EP6 · UniProt P69706

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