MolNFT v1 · #177649 · protein

Crystal structure of ZER1 bound to gklh degron

7EP5 · Protein zer-1 homolog: “Crystal structure of ZER1 bound to gklh degron”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #177649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EP5
Type: protein
Length: 496 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein zer-1 homolog
UniProt: Q7Z7L7
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein zer-1 homolog	protein	252	68% helix, 1% strand	Q7Z7L7
B	Protein zer-1 homolog	protein	244	68% helix, 1% strand	Q7Z7L7

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.34	0.73	22	empty

Interfaces

1 interface between chains.

A–B · 1542 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

7EP5 · Crystal structure of ZER1 bound to GKLH degron · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z7L7 · AlphaFold monomer V2.0 prediction for protein zer-1 homolog (Q7Z7L7) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z7L7
Elsewhere: RCSB PDB 7EP5 · PDBe 7EP5 · UniProt Q7Z7L7

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