MolNFT v1 · #177603 · protein
Wild type of O type foot-and-mouth disease virus
7ENP · VP1 of O type fmdv capsid protein: “Wild type of O type foot-and-mouth disease virus”. Electron microscopy, 6 pockets (best druggability 0.72). MolNFT v1 #177603 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ENP
- Type
- protein
- Length
- 655 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP1 of O type fmdv capsid protein; VP2 of O type fmdv capsid protein; VP3 of O type fmdv…
- UniProt
- Q1KL66
- Pockets
- 6 · best druggability 0.72
Structure
electron microscopy · 4 distinct chains · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | VP1 of O type fmdv capsid protein | protein | 184 | 15% helix, 30% strand | — |
| 2 | VP2 of O type fmdv capsid protein | protein | 206 | 8% helix, 45% strand | — |
| 3 | VP3 of O type fmdv capsid protein | protein | 219 | 8% helix, 33% strand | — |
| 4 | VP4 of O type fmdv capsid | protein | 46 | 22% helix, 0% strand | Q1KL66 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 647 | 0.72 | 0.79 | 77 | empty |
| 2 | 545 | 0.68 | 0.78 | 52 | empty |
| 3 | 401 | 0.67 | 0.80 | 38 | empty |
| 4 | 145 | 0.46 | 0.77 | 23 | empty |
| 5 | 151 | 0.44 | 0.76 | 21 | empty |
Interfaces
6 interfaces between chains.
- 1–2 · 1314 Ų buried · 16 hydrogen bonds · protein-protein
- 1–3 · 1013 Ų buried · 17 hydrogen bonds · protein-protein
- 2–3 · 926 Ų buried · 6 hydrogen bonds · protein-protein
- 1–4 · 790 Ų buried · 12 hydrogen bonds · protein-protein
- 2–4 · 246 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7ENP · wild type of O type Foot-and-mouth disease virus · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1KL66
- Elsewhere: RCSB PDB 7ENP · PDBe 7ENP · UniProt Q1KL66
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