MolNFT v1 · #177585 · protein

Multi-state structure determination and dynamics analysis elucidate a new ubiquitin-recognition mechanism of yeast ubiquitin C-terminal hydrolase.

7EN4 · Ubiquitin carboxyl-terminal hydrolase YUH1: “Multi-state structure determination and dynamics analysis elucidate a new ubiquitin-recognition mechanism of…”. Solution nmr, 4 pockets (best druggability 0.77). MolNFT v1 #177585 on…

PDB: 7EN4
Type: protein
Length: 236 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase YUH1
EC: 3.4.19.12
UniProt: P35127
Pockets: 4 · best druggability 0.77

Structure

solution nmr · 1 distinct chain · 27% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin carboxyl-terminal hydrolase YUH1 (EC 3.4.19.12)	protein	236	27% helix, 14% strand	P35127

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	99	0.77	0.97	24	empty
2	196	0.64	0.83	25	empty
3	78	0.53	0.85	16	empty
4	54	0.29	0.76	13	empty

Compared structures

7EN4 · Multi-state structure determination and dynamics analysis elucidate a new… · the same entry in another collection · chain A against A, TM-score 1.00
P35127 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase YUH1 (P35127) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35127
Elsewhere: RCSB PDB 7EN4 · PDBe 7EN4 · UniProt P35127

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